Indole-3-acetic acid is a tryptophan-derived metabolite produced by intestinal bacteria. It plays a role in gut–liver communication and can affect oxidative stress and intestinal permeability. Elevated IAA may indicate dysbiosis, increased bacterial tryptophan metabolism, or altered liver detoxification pathways. Normal levels suggest balanced gut microbiota activity and effective metabolic clearance.

High IAA levels may suggest an imbalance in gut microbes, excessive bacterial metabolism of tryptophan, or decreased efficiency in liver detoxification. Raised levels can sometimes be associated with oxidative stress or increased intestinal permeability.
Testing IAA can be helpful for individuals experiencing gut-related symptoms, such as bloating or food sensitivities, or those suspected of liver overload. It may also be beneficial for evaluating tryptophan metabolism in people suffering from fatigue, inflammation, or metabolic imbalance.
IAA is produced by gut bacteria from dietary tryptophan. Its levels depend on the diversity of microbes, diet composition, and liver function. Dysbiosis, poor digestion, or impaired detoxification can all increase IAA.
Yes. Supporting a balanced gut microbiota through prebiotic fibres, antioxidants, and reduced exposure to toxins can help regulate IAA production. Promoting liver detoxification and maintaining a nutrient-dense, anti-inflammatory diet also support healthy levels.
