Spermidine is a naturally occurring polyamine involved in cellular growth, repair, and protection. It supports autophagy — the body’s natural process of clearing damaged cells — and contributes to mitochondrial function and longevity pathways. Higher levels are often associated with enhanced cellular renewal and resilience against oxidative stress. Low concentrations may indicate reduced cell turnover, nutritional insufficiency, or increased oxidative demands.

Spermidine is a naturally occurring polyamine that supports cellular growth, repair, and protection. It promotes autophagy – the body’s process of clearing damaged cells – and contributes to mitochondrial efficiency, metabolic balance, and longevity pathways.
Spermidine levels are affected by diet, gut microbial activity, and metabolic health. Foods such as wheat germ, soybeans, mushrooms, and matured cheese are natural sources, while oxidative stress, ageing, and nutrient deficiencies can reduce levels.
Testing can be useful for those interested in longevity, cellular health, or maintaining oxidative stress balance. It may also assist in identifying impaired autophagy or decreased metabolic resilience.
Yes. A nutrient-rich diet, sufficient sleep, physical activity, and supporting gut microbial diversity all help maintain healthy spermidine production. Reducing oxidative stress and keeping polyamine metabolism balanced further support optimal cellular renewal.
