Cortisol Test (Blood)

Cortisol Test in Blood

Cortisol is the primary glucocorticoid hormone produced by the adrenal glands, often referred to as the “stress hormone.” It is essential for regulating metabolism, blood sugar, immune function, inflammation, and the body’s response to physical and emotional stress.

Why measure cortisol?

Cortisol levels that are too high or too low may indicate problems with adrenal function or stress regulation. Elevated cortisol can be linked to chronic stress, insomnia, anxiety, weight gain (especially around the abdomen), or conditions such as Cushing’s syndrome. Low cortisol may be associated with fatigue, low blood pressure, dizziness, or adrenal insufficiency (Addison’s disease). Measuring cortisol provides important information for evaluating adrenal health and identifying possible hormonal imbalances.

Symptoms of high and low cortisol

• High cortisol may cause weight gain (especially around the abdomen), anxiety, sleep problems, high blood pressure, weakened immune function, irregular periods, or mood changes.

• Low cortisol may lead to fatigue, dizziness, low blood pressure, salt cravings, poor stress tolerance, or, in severe cases, adrenal insufficiency.

When should the test be taken?

Because cortisol follows a daily rhythm and peaks in the morning, the test should be performed between 07:00 and 08:00 for the most accurate results.

Who is the test for?

The Cortisol Test (Blood) may be relevant if you experience symptoms such as persistent fatigue, sleep disturbances, mood changes, unexplained weight changes, or suspected adrenal disorders. It can also be useful for individuals under long-term stress or those on treatments that may affect adrenal function.

Key benefits of the Cortisol test

• Measures total cortisol directly in blood
• Provides a reliable assessment of adrenal function
• Useful for investigating symptoms related to stress, energy, and hormonal balance
• Morning testing reflects the body’s peak cortisol production

How the test works

The test is performed using a simple dried blood spot (DBS) sample, collected at home with a finger prick. The sample is then sent to our accredited laboratory for analysis, and results are delivered digitally for secure and convenient access.