Gut Microbiome Test XL

About this test

Key Benefits

• Comprehensive insight into gut microbiome and digestion

• Includes markers for leaky gut (zonulin) and histamine

• Measures bacteria, yeast, inflammation, and digestion

• Helps identify imbalances and root causes

• Simple at-home stool test

What This Test Measures

This test analyzes a wide range of markers, including:

• Gut bacteria: Lactobacillus, Bifidobacterium, E. coli, Clostridium

• Yeast & fungi: Candida spp., Candida albicans, Geotrichum candidum

• Gut pH level

• Digestive enzymes: Pancreatic elastase

• Bile acids – fat digestion

• Inflammation markers: Calprotectin

• Gut barrier markers: Zonulin, Alpha-1 antitrypsin

• Immune markers: Secretory IgA

• Histamine in stool

• Digestive residues: fat, sugar, nitrogen, water

These markers provide a complete overview of gut microbiome, digestion, and gut barrier function.

About Gut Health

The gut plays a central role in nutrient absorption, immune defense, and communication with the brain.

Imbalances in gut bacteria or barrier function (often referred to as “leaky gut”) may allow unwanted substances to pass into the bloodstream, potentially triggering immune responses and inflammation.

By measuring both microbiome and functional markers, this test helps you better understand how your gut may be affecting your overall health.

How It Works

Order your test kit online and collect a stool sample at home using the included kit (multiple tubes). The sample is then sent to the laboratory for analysis, and you receive your results digitally in a clear and easy-to-understand format.

Stool Sample Collection and Test Method

The sample is collected using a simple stool test at home, following the included instructions, and everything you need is included in the kit. The sample is then analyzed to identify and quantify bacteria, yeast, digestive markers, inflammation, and gut barrier parameters.

Accredited Laboratory

The test is analyzed in an accredited laboratory, ensuring high standards for quality, accuracy, and reliability.

Biomarkers included

• Serratia: Serratia is a type of bacteria commonly found in the environment and sometimes in the human intestinal tract. While usually harmless in healthy individuals, its presence in stool may be concerning for those with certain health conditions. Detection in stool tests can signal possible gut flora imbalances or infections.
• Enterococcus species: Enterococcus species are bacteria that can naturally be found in the human gut as part of the normal intestinal microbiome. In balanced levels, they may contribute to microbial diversity and support the overall gut environment. However, higher levels may suggest a shift in microbial balance, especially when seen together with digestive symptoms or other bacterial changes. Enterococcus results shou
• Calprotectin: Calprotectin is a protein found in white blood cells that serves as a marker of inflammation, particularly in the gut. Measuring calprotectin levels in stool helps assess the degree of intestinal inflammation. This test is useful for diagnosing and monitoring inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis, and for distinguishing them from irritable bowel syndrome
• Geotrichum candidum: Geotrichum candidum is a fungus commonly found in the environment, including soil, water, air, and certain foods. It is also a natural part of the human microbiota, typically residing in the gut and on the skin. While usually harmless, it can become opportunistic and cause infections in individuals with weakened immune systems.
• Escherichia coli Biovare: Escherichia coli Biovare is a distinct subspecies of E. coli that is not typically abundant in a healthy human intestine. It includes various forms, such as hemolytic, mucoid, and lactose-negative types. Elevated levels—especially in the presence of alkaline pH and low beneficial E. coli—may suggest weakened mucosal immunity, often linked to reduced secretory IgA production.
• Quantitative Determination of Nitrogen: The quantitative determination of nitrogen (N) is a laboratory test that measures nitrogen levels in bodily excretions, typically urine or feces, to assess protein digestion and absorption. This test is essential for evaluating nutritional status, especially in clinical settings where protein-energy malnutrition or imbalances may be a concern. It provides key insights into metabolic functions rela
• Secretory IgA: The secretory IgA (sIgA) level reflects the amount of an important immune protein called Immunoglobulin A, found mainly in mucosal areas such as the intestines, respiratory tract, and saliva. Secretory IgA plays a vital role in the body’s first line of defense by binding to pathogens and preventing their entry, helping to protect mucosal surfaces and support overall immune and gut health.
• Quantitative Determination of Water: The stool water content analysis is a test that measures the amount of water present in feces. This assessment is important for diagnosing conditions related to abnormal water absorption or secretion in the gastrointestinal tract. It helps identify causes of diarrhea, which may result from infections, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), or malabsorption syndromes, wh
• Escherichia coli: Escherichia coli (E. coli) is a bacterium commonly found in the intestines of humans and animals. Many strains are a normal part of the gut microbiome and can contribute to microbial balance, digestion and vitamin production, including vitamin K. However, some strains of E. coli can be harmful and may be associated with gastrointestinal infection. In a stool profile, E. coli should be interpreted
• Bile acids: Bile acids are compounds essential for digesting fats, produced in the liver and stored in the gallbladder. While most are reabsorbed into the body, a portion is excreted in stool. Measuring bile acids in stool helps assess digestive health, particularly in diagnosing fat malabsorption and related conditions.
• Pancreatic elastase: Pancreatic elastase is an enzyme produced by the pancreas that plays a key role in protein digestion. Measuring its levels in stool can provide important insights into pancreatic function. Because the enzyme remains stable in fecal matter, it serves as a reliable marker for assessing the exocrine function of the pancreas, especially in diagnosing pancreatic insufficiency.
• Hafnia: Hafnia is a genus of bacteria commonly found in the intestinal tract and considered part of the normal gut flora. While typically harmless, its presence in stool may reflect changes in gut microbiota or signal potential digestive imbalances.
• Pseudomonas: Pseudomonas in stool refers to the presence of bacteria from the Pseudomonas genus, most commonly Pseudomonas aeruginosa, in the gastrointestinal tract. While not typically a common gut inhabitant, it can cause infection or overgrowth, particularly in individuals with weakened immune systems. Its detection may indicate an imbalance in gut microbiota or an underlying condition, especially if gastro
• Quantitative Determination of Sugar: The quantitative stool sugar test is a diagnostic tool that measures the amount of specific sugars in stool to assess carbohydrate malabsorption. It helps identify conditions like lactose intolerance, fructose intolerance, and other disorders affecting sugar digestion and absorption. By detecting undigested sugars such as lactose, fructose, or sorbitol in the stool, this test aids healthcare provi
• Klebsiella: Klebsiella is a genus of Gram-negative bacteria present in environments such as soil, water, and the human gut. Certain species, including Klebsiella pneumoniae, can cause serious infections in the lungs, bloodstream, urinary tract, and wounds. These bacteria are notable for their resistance to many antibiotics, making them a significant challenge in healthcare settings.
• Alpha-1 antitrypsin: Alpha-1 antitrypsin (AAT) is a protein mainly produced by the liver that helps protect the lungs and other organs from enzymes that cause inflammation. Measuring AAT levels in feces can help detect intestinal protein loss and inflammation, aiding in the diagnosis of gastrointestinal conditions such as inflammatory bowel disease and protein-losing enteropathy.
• Candida spp: Candida spp is a group of yeast-like fungi that can affect various parts of the body, including the gut and vagina. These fungi often cause symptoms such as itching, discomfort, and discharge, typically resulting from an imbalance in the body’s natural flora. In the gut, Candida spp can interfere with digestion, leading to bloating and changes in bowel habits. Factors such as diet, overall health,
• Yeast/fungus: Yeast is a type of fungus naturally present in the human body, particularly in the gut and on the skin. In normal amounts, it is harmless and part of the healthy microbiome. However, an imbalance can lead to overgrowth, which may cause various health problems. Factors such as diet, antibiotic use, and overall health can affect yeast levels.
• Bifidobacterium: Bifidobacterium is a key genus of beneficial bacteria that primarily inhabit the human gastrointestinal tract. They play an important role in supporting digestion, enhancing immune function, producing essential vitamins, and combating harmful microbes. Maintaining a balanced level of Bifidobacterium is essential for a healthy gut microbiome.
• Proteus: Proteus is a genus of Gram-negative bacteria commonly linked to urinary tract infections (UTIs), especially in individuals with prolonged catheter use or weakened immune systems. They can also cause wound infections and, less frequently, respiratory infections. Proteus species are notable for their resistance to multiple antibiotics, which can make treatment more difficult.
• pH value: The stool pH value is a measure that indicates the acidity or alkalinity in the intestines. It reflects the balance of metabolic processes such as fermentation and protein breakdown. A low stool pH often suggests increased fermentation of complex sugars by intestinal bacteria, which can acidify the stool. Conversely, a high stool pH may result from excessive protein metabolism, leading to the prod
• Histamine in Stool: Histamine (Stool) is a diagnostic marker used to assess allergic and inflammatory activity in the gastrointestinal tract. Histamine is a biogenic amine released by immune cells in response to allergens and plays a key role in inflammation. Elevated stool histamine levels may indicate conditions such as food allergies, inflammatory bowel disease (IBD), or mast cell activation, helping guide diagnos
• Enterobacter: Enterobacter is a genus of bacteria commonly found in the human gut. Usually harmless, these bacteria are part of the natural gut flora and contribute to digestive health. However, an overgrowth of Enterobacter can signal or lead to health problems. Monitoring Enterobacter levels in stool can offer important insights into gut health and aid in diagnosing various conditions.
• Lactobacillus: Lactobacillus is a beneficial bacterium commonly found in the gut and in certain fermented foods. It plays a vital role in supporting digestive health, enhancing nutrient absorption, and maintaining a balanced immune system.
• Clostridium: Clostridium is a genus of bacteria that includes species naturally present in the human gut as well as others that can cause illness. These bacteria are notable for their ability to form spores, allowing them to survive in harsh environments. While some Clostridium species contribute to gut health, others, such as Clostridium difficile, can cause serious infections, particularly after antibiotic u
• Candida albicans: Candida albicans is a type of yeast that can affect different parts of the body, most commonly causing vaginal yeast infections and gut overgrowth. Vaginal infections lead to itching, discomfort, and discharge, often resulting from an imbalance in natural flora. In the gut, overgrowth of Candida albicans can disrupt digestion, leading to bloating and changes in bowel habits. Factors such as diet,
• Quantitative Determination of Fat: The stool fat test is a diagnostic measure that quantifies the amount of fat excreted in stool samples. It is used to assess fat absorption and to detect malabsorption syndromes. Elevated fat levels in stool, known as steatorrhea, can indicate digestive or absorption issues within the gastrointestinal tract. This test aids in diagnosing conditions such as pancreatic insufficiency, cystic fibrosis,
• Bacteriodes: Bacteroides spp. are a key group of bacteria in the human gut microbiome, essential for breaking down complex carbohydrates and producing short-chain fatty acids. These functions support colon health, help regulate the immune system, and protect against harmful pathogens.
• Zonulin: Zonulin is a protein that regulates the permeability of tight junctions between cells in the digestive tract. It plays a key role in maintaining the intestinal barrier by controlling the passage of substances, such as nutrients and antigens, from the gut into the bloodstream. Imbalances in zonulin levels can impact gut permeability, potentially contributing to various health concerns.

How to prepare

**4 weeks before**: Avoid antibiotics. **7 days before**: Avoid probiotics.

Frequently asked questions

Which analysis method is used?

The sample is analysed at an accredited laboratory using a combination of methods: KULTAZ (Culture Analysis) to detect and quantify aerobic and anaerobic bacteria and fungi. VT (Visual Assessment) to evaluate stool characteristics such as colour and consistency. Chemical analysis to measure pH and other properties. Photometric analysis for quantitative measurement of components such as fat, nitrogen, sugar, and water. ELISA (Enzyme-Linked Immunosorbent Assay) to detect specific proteins and enzymes including pancreatic elastase, calprotectin, alpha-1-antitrypsin, and secretory IgA.

How does it work? / When do I get my results?

1. Order and receive your kit. 2. Perform the test. 3. Send a sample at the beginning of the week (to avoid delays). 4. Results digitally in 10–15 business days.

What makes the XL test different from standard gut tests?

This XL version is one of our most comprehensive tests, measuring 29 markers. It includes advanced markers for leaky gut (Zonulin), inflammation (Calprotectin), and a wide range of digestive function markers that are not typically included in standard microbiome screenings.

Customer reviews

4.6/5 (5)

• 4/5 — Good lab test with a solid range of biomarkers for the price.
• 5/5 — The instructions were clear and the kit arrived quickly.
• 4/5 — Results took a full two weeks to arrive, but the depth of the data was worth the wait. It’s quite a lot to digest but very comprehensive.
• 5/5 — Exactly what I needed to check my zonulin levels.
• 5/5 — Really detailed insights that helped me understand my IBS flare-ups better.