Leaky Gut Test

About this test

Key Benefits

• Measures zonulin, a key marker of gut permeability

• Provides insight into gut barrier function

• Helps identify potential imbalances in gut health

• Simple at-home stool test

• Supports understanding of digestive and immune balance

What This Test Measures

This test measures:

• Zonulin

Zonulin is directly involved in regulating the intestinal barrier, making it one of the most relevant markers for assessing gut permeability.

Low & High Zonulin Levels

High zonulin levels may be associated with:

• Digestive discomfort

• Bloating or irregular bowel movements

• Food sensitivities

• Fatigue

• Skin issues

• Inflammation-related symptoms

Low zonulin levels:

• Typically indicate a normal gut barrier function

About Gut Health

The gut plays a key role in nutrient absorption, immune function, and communication within the body. When the gut barrier is compromised, it may influence how the body responds to external substances and internal balance.

This test is designed to provide insight into your gut barrier integrity, helping you better understand potential factors affecting your overall well-being.

How It Works

Order Your Kit: Purchase your test online.
Collect Your Sample: Use the stool collection kit at home.
Send It Back: Mail your sample to the laboratory using the prepaid return envelope.
Receive Results: Access your digital results within 10–15 business days.

Sample Collection

The sample is collected using a simple stool test at home. Everything you need is included in the kit, and the process is easy and hygienic to perform.

Accredited Laboratory

The test is analyzed in an accredited laboratory using the ELISA method, ensuring high standards for quality, accuracy, and reliability.

Biomarkers included

• Zonulin: Zonulin is a protein that regulates the permeability of tight junctions between cells in the digestive tract. It plays a key role in maintaining the intestinal barrier by controlling the passage of substances, such as nutrients and antigens, from the gut into the bloodstream. Imbalances in zonulin levels can impact gut permeability, potentially contributing to various health concerns.

How to prepare

**4 weeks before:** Avoid antibiotics. **7 days before:** Avoid probiotics. **48 hours before:** Headache tablets and anti-inflammatory medications should be avoided as they can otherwise produce false results.

Frequently asked questions

Why does this test specifically measure Zonulin?

Zonulin is currently the only known physiological modulator of intercellular tight junctions. It is the gold-standard biomarker for measuring the integrity of the intestinal wall and identifying increased intestinal permeability.

What do high Zonulin levels mean for my health?

High Zonulin levels indicate that the tight junctions in your gut are opening more than they should. This allows foreign particles to enter the bloodstream, which can trigger immune responses linked to allergies, Celiac disease, Multiple Sclerosis, and various skin conditions.

Can I perform this test entirely from home?

Yes, the kit includes all specialized tools needed for hygienic collection. Once you have collected your stool sample, you use the included pre-paid return shipping materials to send the sample directly to our laboratory for professional analysis.

Is the Leaky Gut Test enough, or should I take a larger gut test?

If you are experiencing complex or severe gastrointestinal issues, you may benefit from more comprehensive screening. For a full map of your microbiome, including parasites, yeast, and additional inflammatory markers, we recommend our Gut Check XL or Gut Check Mega tests.

Customer reviews

4.6/5 (5)

• 5/5 — Got my results in about two weeks and it confirmed what I suspected about my food sensitivities. Glad I finally did this.
• 4/5 — Easy home collection.
• 5/5 — The kit arrived quickly and the instructions were very easy to follow.
• 4/5 — A bit of a wait for the lab results, but the report was professional and easy to understand. Useful for tracking my gut health progress.
• 5/5 — Highly recommend if you have unexplained skin issues.