Sleep Well
GABA and L-theanine with active vitamin B6 (P5P), which contributes to normal nervous system function. One vegan capsule daily, 90 per pack, 3-month supply.
Product details: EUR 29.99 — InStock — SKU INP-SW-B-IO — GetTested
About this supplement
GABA and the Nervous System
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system. It plays a central role in reducing neuronal excitability throughout the nervous system by binding to GABA receptors and inhibiting nerve transmission. GABA is synthesised in the brain from glutamate in a reaction that requires Vitamin B6 (specifically pyridoxal-5-phosphate) as a cofactor. It is one of the most extensively studied compounds in neuroscience and the target of several pharmaceutical drug classes. As an oral supplement, the mechanisms by which exogenous GABA may exert effects are not fully established, though research has identified associations with relaxation markers and there is growing interest in peripheral and gut-brain mechanisms.
L-Theanine: An Amino Acid with a Specific Research Profile
L-theanine is an amino acid found almost exclusively in the leaves of Camellia sinensis (tea). It has a well-documented research profile and is studied for its interactions with GABA receptors and glutamate receptors in the nervous system, as well as its influence on alpha brain wave activity. Research typically uses doses of 100 to 200mg; Sleep Well contains 133mg per capsule. L-theanine does not cause sedation and is generally taken for its association with a calm, relaxed state rather than drowsiness.
Vitamin B6 as P5P: The GABA Connection
Vitamin B6 is included as pyridoxal-5-phosphate, the active coenzyme form the body uses directly. P5P is a required cofactor for glutamate decarboxylase, the enzyme responsible for synthesising GABA from glutamate in the brain. Its inclusion alongside GABA and L-theanine reflects a specific formulation rationale rooted in GABA biosynthesis. At 8.33mg per capsule (595% NRV), it is included at a meaningful dose.
Three Ingredients, One Mechanism
The three ingredients in Sleep Well are connected through GABA metabolism and nervous system function. GABA is the primary inhibitory neurotransmitter. L-theanine interacts with GABA and glutamate receptors. Vitamin B6 as P5P is a cofactor in GABA synthesis. The formula reflects a specific mechanistic relationship rather than a collection of loosely related compounds.
Frequently asked questions
How many capsules are in the container?
90 capsules, a three month supply at the recommended dose of one capsule per day.
Does GABA actually cross the blood-brain barrier?
This is an honest and important question. The blood-brain barrier is largely impermeable to GABA, which means the mechanism by which oral GABA supplementation may exert effects is not fully established. Research has found associations with relaxation markers and there is growing interest in peripheral mechanisms, including gut-brain pathways. The scientific position is that oral GABA has been studied and some effects have been observed, but how exactly it works when taken as a supplement is not yet fully understood.
What is L-theanine and how does it relate to GABA?
Studies on oral GABA supplementation have found real associations with relaxation and reduced stress markers, and the effects themselves are reasonably well documented in research. What scientists are still working out is the precise mechanism behind them. The traditional view was that the blood-brain barrier blocked GABA from entering the brain directly, but more recent research points to other plausible routes: GABA receptors in the gut, signalling through the gut-brain axis, and emerging evidence suggesting the barrier may be more permeable than previously thought. The research shows something is happening. The science on exactly how is still catching up.
Why is Vitamin B6 included alongside GABA?
Pyridoxal-5-phosphate (the active form of B6) is a required cofactor for glutamate decarboxylase, the enzyme that synthesises GABA from glutamate in the brain. Its inclusion is a specific formulation decision rooted in GABA biochemistry, not a generic addition.
Does this product contain melatonin?
No. Sleep Well does not contain melatonin. The formula is built around GABA, L-theanine and Vitamin B6 as P5P. Melatonin has variable regulatory status across EU markets and is absent from this formula by design.
Who should not take Sleep Well?
For adults only. Not suitable for children, or during pregnancy or breastfeeding. If you are taking medication — particularly sedatives, anxiolytics, or other compounds affecting the nervous system — seek medical advice before use. Do not exceed the recommended daily dose.
How should I store it?
In the original sealed packaging, in a dry place away from light at +5 to +25°C.